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Light-driven bacterial inactivation using Plumeria rubra extract: a promising natural photosensitizer

2026Artigo científico Acesso aberto
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datacite.subject.fosCiências Agrárias::Biotecnologia Agrária e Alimentar
datacite.subject.fosCiências Naturais::Ciências Químicas
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
datacite.subject.sdg15:Proteger a Vida Terrestre
datacite.subject.sdg04:Educação de Qualidade
dc.contributor.authorMarcon, Caroline T.
dc.contributor.authorHerculano, Leandro S.
dc.contributor.authorPires, Tânia C.S.P.
dc.contributor.authorCanan, Cristiane
dc.contributor.authorFiorese, Mônica L.
dc.contributor.authorMalacarne, Luis C.
dc.contributor.authorSilveira, Tayse F. F. da
dc.contributor.authorAmaral, Joana S.
dc.contributor.authorBarros, Lillian
dc.date.accessioned2026-09-21T10:29:18Z
dc.date.available2026-09-21T10:29:18Z
dc.date.issued2026
dc.description.abstractAntimicrobial Photodynamic Inactivation (aPDI) is a non-thermal, minimally invasive technique that uses light and photosensitizing compounds (PS) to generate reactive oxygen species, promoting the destruction of microorganisms without inducing microbial resistance. This study investigated the photosensitizing potential of the flower extract of Plumeria rubra L., a unconventional edible plant, in aPDI. The extract showed a high content of rutin, a flavonoid known to confer chemical stability to PS and promote its interaction with bacterial cell structures, increasing photodynamic efficiency. Tests conducted in the dark revealed a lack of antimicrobial activity, a desirable characteristic for photosensitizing compounds. Under white light irradiation and an optical fluence of 18 J/cm2, the extract inactivated the methicillin resistant Staphylococcus aureus strain at a concentration of 0.78mg/mL, in addition to demonstrating action against Listeria monocytogenes and Staphylococcus epidermidis. At an optical fluence of 27 J/cm2, inactivation of most of the strains evaluated was observed. These results indicate that P. rubra extract it is a promising natural photosensitizer, that combines a favorable phytochemical composition, absence of inactivation in the dark, and high photodynamic efficiency under white light, demonstrating potential for therapeutic and industrial applications.eng
dc.description.sponsorshipThe authors thank the Brazilian National Council for Scientific and Technological Development (CNPq), processes: 200176/2024-2, 442004/2023-0, 420280-2023-5, 303635/2022-3, 301558/2022-1. This work was also supported by national funds from FCT – Fundação para a Ciência e a Tecnologia: CIMO UID/00690/2025, UID/6157/2025 and UID/PRR/00690/2025. SusTEC, LA/P/0007/2020. L. B. Barros thanks FCT through the institutional scientific employment program–contract for her contract CEEC-INST, DOI: 10.54499/CEECINST/00107/2021/CP2793/CT0002. The Article Processing Charge (APC) for the publication of this research was funded by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superio do Brasil (CAPES).
dc.identifier.citationMarcon, Caroline T.; Herculano, Leandro S.; Pires, Tania C. S. P.; Canan, Cristiane; Fiorese, Monica L.; Malacarne, Luis C.; Silveira, Tayse F. F.; Amaral, Joana A. S.; Barros, Lillian (2026). Light-driven bacterial inactivation using Plumeria rubra extract: a promising natural photosensitizer. International Microbiology. ISSN 1139-6709. 29:6, p. 839-850
dc.identifier.doi10.1007/s10123-026-00818-z
dc.identifier.issn1139-6709
dc.identifier.urihttp://hdl.handle.net/10198/37154
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer
dc.relationCIMO - Mountain Research Center - UID/PRR/00690/2025
dc.relationLiveWell
dc.relationMountain Research Center - UID/00690/2025
dc.relationAssociate Laboratory for Sustainability and Tecnology in Mountain Regions - LA/P/0007/2020
dc.relationInvestigação em alimentos e soluções de base biológica - CEECINST/00107/2021/CP2793/CT0002
dc.relation.ispartofInternational Microbiology
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectNon-conventional edible plants
dc.subjectAntimicrobial photodynamic therapy
dc.subjectPlant-derived compounds
dc.subjectBioactive extracts
dc.titleLight-driven bacterial inactivation using Plumeria rubra extract: a promising natural photosensitizereng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUID/PRR/00690/2025
oaire.awardNumberUID/00690/2025
oaire.awardNumberLA/P/0007/2020
oaire.awardNumberCEECINST/00107/2021/CP2793/CT0002
oaire.awardTitleCIMO - Mountain Research Center - UID/PRR/00690/2025
oaire.awardTitleLiveWell
oaire.awardTitleMountain Research Center - UID/00690/2025
oaire.awardTitleAssociate Laboratory for Sustainability and Tecnology in Mountain Regions - LA/P/0007/2020
oaire.awardTitleInvestigação em alimentos e soluções de base biológica - CEECINST/00107/2021/CP2793/CT0002
oaire.awardURIhttp://hdl.handle.net/10198/36356
oaire.awardURIhttps://livewell.ipb.pt
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT
oaire.awardURIhttps://doi.org/10.54499/CEECINST/00107/2021/CP2793/CT0002
oaire.citation.endPage850
oaire.citation.issue6
oaire.citation.startPage839
oaire.citation.titleInternational Microbiology
oaire.citation.volume29
oaire.fundingStreamCIMO
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNamePires
person.familyNameSilveira
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person.givenNameTânia C.S.P.
person.givenNameTayse F. F. da
person.givenNameJoana S.
person.givenNameLillian
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person.identifier.ciencia-id9616-35CB-D001
person.identifier.orcid0000-0002-3954-3833
person.identifier.orcid0000-0002-3648-7303
person.identifier.orcid0000-0002-9050-5189
person.identifier.ridQ-2842-2018
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person.identifier.scopus-author-id57057440000
person.identifier.scopus-author-id35236343600
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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