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Light-driven bacterial inactivation using Plumeria rubra extract: a promising natural photosensitizer
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Orientador(es)
Resumo(s)
Antimicrobial Photodynamic Inactivation (aPDI) is a non-thermal, minimally invasive technique that uses light and photosensitizing compounds (PS) to generate reactive oxygen species, promoting the destruction of microorganisms without inducing microbial resistance. This study investigated the photosensitizing potential of the flower extract of Plumeria rubra L., a unconventional edible plant, in aPDI. The extract showed a high content of rutin, a flavonoid known to confer chemical stability to PS and promote its interaction with bacterial cell structures, increasing photodynamic efficiency. Tests conducted in the dark revealed a lack of antimicrobial activity, a desirable characteristic for photosensitizing compounds. Under white light irradiation and an optical fluence of 18 J/cm2, the extract inactivated the methicillin resistant Staphylococcus aureus strain at a concentration of 0.78mg/mL, in addition to demonstrating action against Listeria monocytogenes and Staphylococcus epidermidis. At an optical fluence of 27 J/cm2, inactivation of most of the strains evaluated was observed. These results indicate that P. rubra extract it is a promising natural photosensitizer, that combines a favorable phytochemical composition, absence of inactivation in the dark, and high photodynamic efficiency under white light, demonstrating potential for therapeutic and industrial applications.
Descrição
Palavras-chave
Non-conventional edible plants Antimicrobial photodynamic therapy Plant-derived compounds Bioactive extracts
Contexto Educativo
Citação
Marcon, Caroline T.; Herculano, Leandro S.; Pires, Tania C. S. P.; Canan, Cristiane; Fiorese, Monica L.; Malacarne, Luis C.; Silveira, Tayse F. F.; Amaral, Joana A. S.; Barros, Lillian (2026). Light-driven bacterial inactivation using Plumeria rubra extract: a promising natural photosensitizer. International Microbiology. ISSN 1139-6709. 29:6, p. 839-850
Editora
Springer