Development of an efficient hypocholesterolemic formulation from mushroom bioresidues through a sustainable integrated strategy.

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Organização

Publicações

Gut Microbiota as an Endocrine Organ: Unveiling Its Role in Human Physiology and Health

Publication . Pires, Lara; Gonzalez-Paramás, Ana Maria; Heleno, Sandrina A.; Calhelha, Ricardo C.

The gut microbiota, recognised for its vital functions in host health, operates as an endocrine organ, exerting systemic effects beyond the gastrointestinal tract. This “virtual organ” produces hormones that influence distal organs, including the brain. With its diverse microbial composition, the gut microbiota surpasses the biochemical complexity of traditional endocrine organs, generating neurotransmitters like GABA, dopamine, and serotonin. Despite challenges in culturing gut bacteria, advances in research methodologies have elucidated their role in behaviour, metabolism, appetite, and insulin resistance. As microbial endocrinology continues to evolve, further exploration of the intricate connections between hormones and the microbiome are anticipated, highlighting hormones’ pivotal role in the dynamic host–microbiota relationship.

2024Artigo científico

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Mushroom bioresidues as sources of bioactive compounds: obtaining ergosterol and statins from Pleurotus ostreatus L. – assessment of antioxidant and prebiotic potential

Publication . Ayari, Nour; Heleno, Sandrina A.; Xavier, Virginie; Saafi, Emna Behija

The valorization of bio-residues generated during the production of Pleurotus ostreatus represents a sustainable strategy to reduce waste while recovering compounds with health-promoting potential. In this work, misshapen mushroom fruiting bodies a commonly discarded by-product were explored as a source of ergosterol and natural statin-like molecules (lovastatin and pravastatin). Two extraction methodologies, Heat-Assisted Extraction (HAE) and Ultrasound-Assisted Extraction (UAE), were optimized using Response Surface Methodology (RSM) to assess the combined effects of extraction time, temperature or ultrasonic power, and solvent composition on the recovery of these compounds.

2026Dissertação de mestrado

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Entidade financiadora

Fundação para a Ciência e a Tecnologia

Programa de financiamento

Concurso de Projetos de I&D em Todos os Domínios Científicos - 2022

Número da atribuição

2022.08844.PTDC